A Random Walk in Science, by Robert L. Weber

By Robert L. Weber

This anthology presents an perception into the wit and mind of the clinical brain via a mix of a laugh and severe contributions written through and approximately scientists. The contributions list altering attitudes inside of technology and reflect the interactions of technology with society.

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2000). The result of these studies are not always consistent, however, they do indicate that an integron and gene cassettes are also likely to be present in many, but not necessarily all, Vibrio species. The partially sequenced intI5 gene from V. , 2000). , 2001). SOME INTEGRONS CAN MOVE In the gene cassette/integron system, it is the cassettes that are the mobile elements. However, in the context of their contribution to horizontal gene transfer, it is obvious that integrons and gene cassettes can have a substantial impact, as is the case with respect to antibiotic resistance, only if the integron can gain wide access to a variety of bacterial species.

The distance between 1L and 2L is 5 bp, but either 5 or 6 bp separate 2R from 1R. It remains to be established which of the differences between the LH and RH simple sites are important in ensuring that the recombination crossover occurs at 1R. CONCLUSIONS The role of gene cassettes and integrons in the emergence and spread of antibiotic resistance is well established. The same system has now been implicated in the evolution of bacterial genomes, and the extent of this involvement already appears to be quite significant.

H. (1987) Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 β-lactamase gene. Proc. Natl Acad. Sci. USA 84: 7378–7382. , Scaramuzzi, C. et al. (2000) Definition of the attI1 site of class 1 integrons. Microbiology 146: 2855–2864. W. M. (2001a) Transposons Tn1696 and Tn21 and their integrons In4 and In2 have independent origins. Antimicrob. Agents Chemother. 45: 1263–1270. W. M. (2001b) A family of class 1 integrons related to In4 from Tn1696.

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A Random Walk in Science, by Robert L. Weber
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